| ISSN No. : | 2349-7181 |
| Journal Title : | Acute Phase Treatment for Infants Younger Than 1 Year of Age with Kawasaki Disease: A Single Center Retrospective Study |
| Journal URL : | https://www.advancedresearchpublications.com/ |
| Publisher Name : | Shalini Agnihotri |
| Country : | India |
| Language : | English |
| Discipline : | Multidiciplinary |
| Organization Name : | Advance Research Publications |
| Frequency : | Annual |
| Start Year : | 2018 |
| Journal Description : | Kawasaki disease (KD) is acute systemic vasculitis of
unknown cause that majorly affects the infants and child
populations.1 Coronary artery lesions (CAL) are a severe
complication of KD. Infants younger than 1 year of age with
KD have a high risk for CAL including giant aneurysmus.2-4
However, the appropriate acute phase treatment for the
infants has not been established.
At present, the standard therapy for the acute phase of
this disease is intravenous immunoglobulin (IVIG) therapy
at 2 g/ kg/ dose with the concomitant use of medium-or
higher-dose aspirin.5 However, the concomitant use of
medium- or higher-dose aspirin is now controversial.6 A
randomized controlled trial regarding the effectiveness
of intravenous immunoglobulin alone and intravenous
immunoglobulin combined with high-dose aspirin in the
acute stage of KD is ongoing.7
Recent studies have suggested that aspirin may inhibit
CAL prevention.8,9 The delayed use of aspirin (DUA) may be
beneficial for the prevention of coronary artery stenosis in
KD.8, 10-12 This study aimed to ascertain the usefulness of an
initial single IVIG therapy (2 g/ kg/ dose) with DUA for the
infants younger than 1 year of age with KD. |
| Licence Type : | CC BY |