OBJETIVO: Detecção de Ehrlichia canis, Rickettsia rickettsii, Anaplasma platys, Rangelia vitallii, Babesia canis vogeli por meio de PCR em tempo real em cães atendidos no hospital veterinário da Universidade Santo Amaro, localizado na zona sul, do município de São Paulo, SP, Brasil. MÉTODOS: Foi realizada extração de DNA de 63 amostras de sangue total pelo “kit” de extração “PureLink Genomic DNA Kit” (Invitrogen®) conforme instruções do fabricante e realizada a PCR em tempo real para a detecção de Ehrlichia canis, Rickettsia rickettsii, Anaplasma platys, Rangelia vitallii, Babesia canis vogeli. RESULTADOS: 23,8% (15/63) das amostras foram positivas na PCR em tempo real para pelo menos um agente patogênico. Destas, 9,52% (6/63) foram positivas para Babesia canis vogeli e 14,2% (9/63) para Ehrlichia canis. Nenhuma amostra foi positiva para Rickettsia rickettsii, Rangelia vitalli e Anaplasma platys. CONCLUSÃO: Este estudo demonstrou a presença de B. canis vogeli e E. canis em cães de áreas de fragmentação de Mata Atlântica aos arredores da represa Guarapiranga da cidade de São Paulo de maneira inédita, ampliando o conhecimento da dispersão desse agente no país.

OBJECTIVE: To demonstrate that lurasidone can be an alternative for adolescents with Autistic Spectrum Disorder (ASD), especially if the patient has a history of adverse metabolic effects and / or ineffectiveness or intolerance to the use of aripiprazole or risperidone. METHODS: Systematic review of articles from the PubMed platform, with only articles in Portuguese and English being selected, with no period limitation. Inclusion criteria for the study: studies that address the treatment of ASD; studies that address treatment focusing on the use of lurasidone; works that bring clear methodology. RESULTS: Lurasidone has shown promise, given its low profile of adverse effects, such as lower weight gain, hyperlipidemia, hyperglycemia and insulin resistance. In addition to the potential benefits of lurasidone for the treatment of irritability in children with ASD, there may also be a potential antidepressant effect, which may influence the symptom profile. It is currently approved by the Food and Drug Administration (FDA) for the treatment of schizophrenia in adolescents from the age of thirteen and on monotherapy for bipolar depression from the age of ten. However, there are studies of tolerance in children and adolescents from the age of six with doses <120 mg / day. CONCLUSION: Given the risk of long-term adverse metabolic effects of most atypical antipsychotics, lurasidone can serve as an alternative. However, to date, no evidence has been found consistent with the use of lurasidone for patients with ASD who exhibit irritability, aggressiveness and impulsivity as associated symptoms.

OBJETIVO: A entrada na Universidade constitui um desafio de autonomia e afirmação própria/de grupo. Os comportamentos saudáveis devem merecer uma atenção particular de todos os intervenientes e do meio universitário em geral. Este estudo visou conhecer os estilos de vida dos alunos do primeiro ano da Universidade Católica Portuguesa – Porto (UCP). MÉTODOS: Procedeu-se à aplicação do questionário “Estilo de Vida Fantástico” nas sessões letivas de “Pensamento Crítico”. Os dados colhidos foram tratados no programa SPSS®. RESULTADOS: Verificou-se que o estilo de vida global destes alunos considerar-se “bom” não se registando diferenças entre os sexos. Contudo, 7,9% dos alunos situam-se nos valores mais baixos da categoria. Os itens em cujo afastamento mais se acentuou foram: atividade física/associativismo, trabalho/tipo de personalidade, nutrição e comportamento de saúde/sexual. Destacou-se com peso elevado o item “família/amigos”. CONCLUSÃO: Concluiu-se que o “Fantástico” foi o primeiro passo para um diagnóstico e ponto de partida para avaliar as necessidades destes estudantes. Embora a situação se possa considerar favorável importa desde já programar intervenção seja de promoção na componente atividade física/associativismo e nutrição seja de controlo no âmbito do consumo de tabaco e álcool.

OBJECTIVE: To employ the Wood-Downes Score and the upper airway obstruction score proposed by Downes and Raphaelly in the assessment of respiratory patterns and the indication of oxygen and ventilation support devices after orotracheal extubation. METHODS: It is a cross-sectional, descriptive, and quantitative study. The group was composed of 15 infants aged 28 days to 2 years old, hospitalized at the pediatric intensive care unit from august to october 2018, fulfilling the inclusion criteria and following the ethical in research aspects. RESULTS: Out of fifteen infants in the sample, 66,66% were female. The mean age was 6,4 ±6,27 months. The most common Wood-Downes score at baseline was moderate with mean 3,4 ±1,91, going to mild 1,6 ±0,89 at the second moment. The mean upper airway obstruction score at baseline was 2,9 ±1,62 decreasing to 1,7 ±0,79 at the second moment. CONCLUSION: The employment of the Wood-Downes Score and the upper airway obstruction score proposed by Downes and Raphaelly to assess the respiratory patterns in the present study, showed efficacy in the indication of non-invasive ventilatory support because the moderate score was the most present. Although the study did not interfere in the medical conduct, it is believed that the scores employed are useful tools to the control and assessment of the acute respiratory insufficiency after infant extubation.

OBJETIVO: Comparar as dificuldades enfrentadas pelos profissionais de saúde das redes públicas e privadas durante a pandemia de COVID-19. MÉTODOS: A partir de um formulário disponibilizado via online para profissionais de saúde, foi questionado quais as principais dificuldades no enfrentamento da pandemia de COVID-19 como: falta de EPIs, leitos, profissionais, número de pacientes, recebimento de treinamento especializado nos sistemas de saúde público e privado. Resultados: Foram obtidas 389 respostas. Entre as pessoas que o preencheram, 256 eram pertencentes apenas ao setor público e 82 apenas ao setor privado, sendo que 52 delas trabalhavam em ambos. Foi possível perceber a desproporcionalidade de dificuldades encontradas nos dois setores, tendo os profissionais da rede pública se deparado com mais problemas. A falta de EPIs, por exemplo, se demonstrou maior no setor público. 42,6% dos seus integrantes que responderam à pesquisa relataram sua escassez em algum momento, sendo que apenas 17,1% dos integrantes da rede privada o fizeram. Quanto ao número de profissionais infectados, o âmbito público também apresentou desvantagens, uma vez que 33,6% dos participantes da rede pública foram infectados, um número maior que o 20,7% resultante do âmbito privado. A diferença na falta de leitos, entretanto, não foi estatisticamente relevante pelo chi-quadrado. CONCLUSÃO: Concluímos que em muitos quesitos, os profissionais integrantes da rede pública estão em desvantagem em relação aos da rede privada. Fatores como a falta de EPIs e número de profissionais infectados se mostraram altamente desproporcionais em ambos os setores.

OBJECTIVE: To identify the adequacy of good practices in two restaurants of two American fast-food franchises in the city of São Paulo, SP, Brazil. METHODS: A checklist adapted from the health legislation was used in each restaurant, identified as A and B, whose items were grouped into 5 blocks: Building and installation, Equipment, furniture and utensils, Handlers, Food production and transportation, and Documentation. The classification of the restaurants was based on the sanitary legislation: group 1, between 75 and 100% of conformities; group 2, between 51 and 74% of conformities; and group 3, from 0 to 50% of conformities. The general classification of the restaurants and by block of items was carried out. RESULTS:Restaurant A was classified in group 2 and B in group 1. Most of the non-conformities were observed in the blocks Documentation, Production and transport, and Manipulators for both restaurants; and Building and installation for restaurant A. CONCLUSION: Restaurant B had a higher percentage of conformities than restaurant A, and the classification was group 1 and 2, respectively. Regardless of the classification, both presented non-conformities relevant to the safety of the food produced. Based on that, it is suggested to apply an action plan to adapt to the current legislation, guaranteeing quality to food and health to consumers.

OBJECTIVE: To characterize the management of mechanical ventilation, ventilatory weaning and tracheal extubation in the Pediatric Intensive Care Centers (PICC) of the Hospital Geral do Grajaú. METHODS: Prospective observational study conducted at the Pediatric Intensive Care Center (PICC) of the Hospital Geral do Grajaú (HGG) for 9 months. RESULTS: Ninety patients who were under mechanical ventilation were included in the study. Of these, 40 were girls and 50 were boys. With a mean age of 5.52 months. Respiratory diseases were diagnosed with hospitalization in 84 patients (93.3%). In 100% of the cases, the Ventilatory Mode Controlled Pressure after tracheal intubation was used. Patients were submitted to MV on average for 6.6 days. In 89 patients (98.8%), the ERT with PSV was performed. Seventy-three patients (81.1%) used NIV after extubation with an average of 2 days of use. In 81 patients (90%) extubation was successful. CONCLUSION: The pediatric population hospitalized in pediatric intensive care units requiring the use of invasive mechanical ventilation is mostly male, less than 6 months old, with indication for hospitalization for respiratory disorders. The use of invasive ventilatory support was on average 6.6 days. Success of tracheal extubation in 90% of patients. We suggest greater accuracy regarding the descriptions of health professionals in electronic medical records.

OBJECTIVE: Trypanosoma theileri is the type species of the subgenus Megatrypanum, first registered in cattle in South Africa and East Africa. Cattle farms in the extreme south of the municipality of São Paulo and Embu-Guaçu, are characterized as subsistence, on small properties, and 500 head of cattle were registered in 2019. This work aimed to evaluate the occurrence of T. theileri in cattle from family farms in the extreme south of the city of São Paulo and in the municipality of Embu-Guaçu, SP, Brazil. METHODS: Parasitological and molecular diagnoses were carried out on samples taken from 68 cattle in small farms in the extreme south of São Paulo. RESULTS: The specific molecular diagnosis of T. theileri was 17.6% positive (12/68) and the parasitological diagnosis was 5.8% (4/68). CONCLUSION: Although considered non-pathogenic, its presence in the host may favor other parasitic and infectious diseases.

OBJECTIVE: The objective of this study was to evaluate the impact of the COVID-19 pandemic over the search for healthcare services according to four criteria (cancellation of medical consultations, suspension of treatments, postponement of surgeries and non-performance of routine tests), comparing the results between genders and age groups. METHODS: A survey was conducted through an internet questionnaire in October 2020. RESULTS: 602 responses were obtained, and the results were that women had lower rates of going to health services compared to men and individuals belonging to the elderly age group canceled more medical visits, interrupted more therapies, and postponed more surgeries than other age groups. CONCLUSION: Considering the overview of all age groups, the pandemic caused a decrease of about 28% in the demand for medical consultations and this decrease is more significant among the elderly and women. These results emphasize the need for specific campaigns for these people in periods of social isolation due to the pandemics.

OBJECTIVE: To evaluate the efficacy and safety of Venlafaxine for the control of vestibular migraine (VM). METHODS: This is a systematic review of randomized clinical trials. The following databases were searched: PUBMED (1966-2021), EMBASE (1974-2021) and CENTRAL (Cochrane Library-2021). There was no geographic and period limitation in the survey. Data extraction and study quality assessment were carried out by two independent researchers. RESULTS: The search strategy identified 47 studies, of which 2 were included in this review, as they met the inclusion and exclusion criteria. Both evaluated the efficacy of venlafaxine in vestibular migraine, comparing the results with other drugs. The first study (2017) compared the effect of venlafaxine with flunarizine and valproic acid, while the second study (2015) compared the efficacy of venlafaxine with propranolol. Both showed improvement of vestibular symptoms in all groups evaluated, but only the groups submitted to treatment with venlafaxine showed a significant change in the emotional DHI (Dizziness Handicap Inventory) score and improvement in depressive symptoms. CONCLUSIONS: Although venlafaxine appears to have promising results, there is currently a scarcity of studies that allow currently to assess the efficacy and safety of the drug for the treatment of vestibular migraine. The evidence is quite limited, the number of studies and patients evaluated reduced, and it is recommended to conduct new quality randomized clinical trials to elucidate the issue.